Prognostic factors of ALL
- Age: This is considered the most important prognostic factor, as younger patients usually have a more favorable prognosis, while people over 70 have an adverse prognosis.
- White blood cell count: People whose white blood cell count is lower at diagnosis have a better prognosis.
- Translocations: Adverse prognosis is seen when there has been translocation in chromosomes 4 and 11, presence of an additional 8 chromosome, lack of chromosome 7, and presence of the Philadelphia chromosome.
- ALL subtype: T-cell ALL usually has a better prognosis, while mature B-cell ALL has a more unfavorable prognosis.
- CNS infiltration: Involvement of ALL in the CNS is associated with greater risk of relapse.