Prognostic factors are measurable circumstances that will influence patient survival.

The most common prognostic factors for CLL include the following:

• Clinical factors: Rai staging and Binet staging focus on adenopathy in the patient and on anemia and thrombocytopenia (not of an autoimmune origin).
• Biological factors: The disease can be detected using flow cytometry based on biomarkers such as ZAP70 and CD38. Cytogenetic/FISH search for chromosome 11 deletions (ATM gene) or chromosome 17 deletions (p53 gene).